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Schumanniophyton problematicum
Schumanniophyton problematicum is a species of plant in the family Rubiaceae. It is found in Ivory Coast, Ghana, and Sierra Leone. It is threatened by habitat loss.
The plant has been found to contain the alkaloids rohitukine and rohitukine N-oxide, and the iridoid glycosides scyphiphorin A1–A2 and scyphiphorin B1–B2. Alvocidib is a synthetic analog of rohitukine that acts as a CDK9 kinase inhibitor and is under clinical development for the treatment of acute myeloid leukemia. It has also been studied for the treatment of arthritis and atherosclerotic plaque formation
Rohitukine was initially extracted from Aphanamixis polystachya (the alkaloid name being derived from the synonym Amoora rohituka) and later from Dysoxylum binectariferum. - both of which plant species belong to the family Meliaceae.
Text excerpted from the Wikipedia article Schumanniophyton problematicum by its contributors, under CC BY-SA 4.0; the excerpts are shared under the same licence.
Life form, climate and native range: World Checklist of Vascular Plants, Royal Botanic Gardens, Kew (CC BY 3.0), reformatted; see Plants of the World Online.
